Sumary of Emerging SARS-CoV-2 mutations L452R & Y453F evade cellular immunity:
- The coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread globally, with the total number of cases reaching over 191 million.
- Despite vaccination efforts, many SARS-CoV-2 variants with naturally acquired mutations have emerged.
- Researchers at the Kumamoto University and Weizmann Institute of Science found that the L452R mutation of the SARS-CoV-2 spike protein, which is common to two mutant strains, the Epsilon and Delta, can evade cellular immunity through the human leukocyte (HLA) A24 and can increase viral infectivity.
- Microbe, also showed emerging mutations L452R and Y453F in the SARS-CoV-2 spike receptor-binding motif evade (HLA) A24-restricted cellular immunity.
- Meanwhile, the L452R enhances spike stability, viral fusogenicity, and viral infectivity.
- Hence, the findings suggest that HLA-restricted cellular immunity potentially affects the evolution of viral phenotypes.
- SARS-CoV-2 mutants Though vaccination efforts have commenced in most countries and over 3.71 billion doses have already been administered, the threat of COVID-19 is far from over.
- The first reported and well-studied mutant contains a D614G substitution in the spike (S) protein.