flu shots and covid 19 immunity

Sumary of Flu shots and COVID-19 immunity:

  • A new paper published on the preprint server medRxiv* finds that the influenza vaccine may influence both the response to and incidence of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • The researchers of the current study present evidence that those who took the flu shots experienced an immune response that reduced their risk of the coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, by 37% during the first wave of the pandemic, and by almost half in the second wave.
  • Study: Induction of Trained Immunity by Influenza Vaccination – Impact On COVID-19. Image Credit: Design_Cells / Shutterstock.
  • Several other vaccines, such as the bacilli Calmette-Guerin (BCG) vaccine against tuberculosis, have non-specific effects on immunity and can thus enhance the innate immune response against pathogens in general over the long term.
  • They examined the blood cells of the study participants before and after vaccination.
  • To this end, changes in the transcription profile of both lymphoid and myeloid cells, particularly in CD14+ monocytes, were observed.
  • These innate immune cells showed differences in the regulation of 136 genes, very similar to the pattern seen in CD4+ naïve T-cells.
  • The expression of myeloid cell nuclear differentiation antigen (MNDA) and cathepsin S (CTSS) was much higher than the baseline following flu vaccination.

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