‘Gold Standard’ Study Confirms mRNA Vaccines Prevent Infection Clinical trials of mRNA vaccines have consistently demonstrated high effectiveness against COVID-19, but now a large, real-world study confirms that the Pfizer-BioNTech and Moderna vaccines ar

gold standard study confirms mrna vaccines prevent infection clinical trials of mrna vaccines have consistently demonstrated high effectiveness against covid 19 but now a large real world study co

Sumary of ‘Gold Standard’ Study Confirms mRNA Vaccines Prevent Infection Clinical trials of mRNA vaccines have consistently demonstrated high effectiveness against COVID-19, but now a large, real-world study confirms that the Pfizer-BioNTech and Moderna vaccines are more than 95% effective in preventing confirmed infection.:

  • Similar rates of effectiveness of the COVID vaccines approved in the United States had been shown in clinical trials, but this is among the first large studies to show how the vaccines work outside a cohort of volunteers in a controlled setting.
  • The study, which was published in Annals of Internal Medicine on Monday, included 54,360 people who tested positive for SARS-CoV-2 infection in the U.S. Department of Veterans Affairs healthcare system and 54,360 propensity score–matched control participants.
  • Gold Standard Methodology Butt says the VA population was chosen because it is one of the largest integrated health systems in the nation and has a single electronic health records platform.
  • He explains that the methodology they used, test-negative case–control design, is the gold standard for vaccine effectiveness studies.

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