High single-dose efficacy of Pfizer vaccine against SARS-CoV-2 in older adults

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Sumary of High single-dose efficacy of Pfizer vaccine against SARS-CoV-2 in older adults:

  • In British Columbia (BC), Canada, vaccination against coronavirus disease 2019 (COVID-19) began with the Pfizer/Moderna mRNA (messenger ribonucleic acid) vaccines began with nursing home residents and frontline healthcare workers..
  • New research by scientists in Canada suggests that these are known to have a high protective efficacy of 92-93% after a single dose, but this data comes from younger and healthy adults, for the most part..
  • Background Since vaccine stocks are in short supply, many countries resorted to lengthening the interval between doses to increase single-dose coverage, thus protecting more people in a shorter time..
  • This has made it difficult to differentiate direct and indirect vaccine effects, as well as the effect of the first dose as compared to that of both doses..
  • Those who had positive virus tests by reverse transcriptase-polymerase chain reaction (RT-PCR) on specimens between weeks 14-17 from the start of the pandemic in BC were included..
  • Community testing based on symptoms was used to identify real-life vaccine efficacy against all variants, including VOCs, after one dose of an mRNA vaccine..
  • Related Stories Vaccine coverage (prime dose) among both cases and controls reached 85% and 90%, by week 14, 85% with the Pfizer vaccine..
  • Vaccination associated with 65% fall in cases The findings show that vaccine efficacy (VE) was insignificant until two weeks after vaccination, increasing over the next week to 43% at 14-20 days….

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