Sumary of Innate immunity key to limiting viral load in COVID-19 cases:
- As the coronavirus disease 2019 (COVID-19) pandemic continues to cause many difficulties for public health authorities, research is ongoing to understand how the virus can cause fatal effects on those infected and thereby suggest effective preventive and therapeutic measures against it..
- A new study conducted by researchers at the Houston Methodist Hospital, Rutgers University, and other institutions has been published on the preprint server medRxiv.* Its findings show the central role that innate immunity can play in controlling the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19..
- Modeling Virus-Receptor Interactions Mathematical modeling of the SARS-CoV-2 infection has shown its importance in arriving at a better understanding of the viral dynamics and the disease’s pathophysiology..
- Therefore, such a diagnosis must be supported by the detection of viral RNA by RT-PCR testing (specimens from both upper and lower respiratory tracts) and pulmonary CT scans..
- Connectivity diagram between compartments indicating viral transport mechanisms, cell populations, immune system agents, and their interactions..
- Utility of Mathematical Modeling in COVID-19 With limited data on the viral dynamics in living organisms, mathematical modeling at various scales has been widely adopted to fill out the current knowledge of virus-host interactions at molecular, cellular, tissue, organ, and organism levels..
- Others have modeled the interactions between both the infected and the immune cells as well as the relationship between infectiousness and severity of the disease..
- Thus, the predicted persistence of the virus in organs other than the lungs and in the blood is for around 17 to 20 days after the earliest symptom, which matches published studies and compares well with the known duration of viral load in the upper and lower respiratory tract infections….