Sumary of Instability in gut microbiota associated with COVID-19-related complications and mortality, study finds:
- They performed 16S rRNA gene sequencing on the fecal and saliva samples taken from 108 COVID-19 patients and 22 post-COVID-19 patients, as well as 20 controls with pneumonia and 26 asymptomatic controls.
- Left histogram shows the richness and right histogram Shannon effective number of species.
- Stacked barplots show taxonomic distribution on phyla level.
- D Left, alpha-diversity stratified according to SARS-CoV-2 status for all samples of all patients, showing Shannon effective numbers and richness.
- Right, bar plots show effect modifiers significantly contributing to microbial diversity in all samples.
- COVID-19 complications and severity correlate with gut and oral microbiota Related StoriesThe results showed that gut and oral microbiota were altered based on the number and type of COVID-19-related complications and disease severity.
- Occurrence of individual complications correlated with the presence of low-risk bacteria such as Faecalibacterium prausznitzii and high-risk bacteria such as Parabacteroides in the gut.
- The analysis demonstrated that a stable gut bacterial composition correlated with a favorable disease progression and identified a model based on gut microbial profiles to estimate COVID-19 mortality.