Sumary of Low dose of Moderna COVID-19 vaccine generates durable immune response:
- A new study from La Jolla Institute for Immunology (LJI) scientists helps answer the question: how long does immunity against COVID-19 last in vaccinated people?
- As they report in Science, a low dose of the Moderna vaccine lasts for at least six months, and there is no indicator that vaccinated people will need a booster shot.
- “This time point is critical because that is when true immune memory has formed,” says LJI Research Assistant Professor Daniela Weiskopf, Ph.
- , who co-led the study with LJI Professors Alessandro Sette, Dr.Biol.
- In fact, while the Moderna COVID-19 vaccine (mRNA-1273) led to strong CD4+ (helper) T cell, CD8+ (killer) T cell and antibody responses for at least six months after clinical trial participants were fully vaccinated, it is likely that the immune response could last much longer.
- The researchers also show that this strong immune memory lasted in all age groups tested, including in people over age 70, a demographic especially vulnerable to severe COVID-19. “The immune memory was stable, and that was impressive,” adds Crotty.
- ” Comparing Moderna vaccine to natural immunity The researchers compared recovered COVID-19 patients to vaccine trial participants who received a 25-microgram dose of the Moderna vaccine during the phase 1 clinical trials (supported by the National Institute of Allergy and Infectious Diseases, National Institutes of Health).
- “We had the opportunity to receive the samples from the original Moderna/ NIH phase 1 trial participants who had received two 25-microgram injections of the vaccine, 28 days apart.