Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19

Sumary of Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19:

  • The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has challenged healthcare facilities globally.
  • The RNA interference, propitiated by artificially created small interfering RNA (siRNA), is a possible strategy to repress RNA virus replication, presentation of viral antigens, and other viral genes.
  • Antiviral-siRNA therapies have been successfully applied against various fatal pathogenic human respiratory viruses, including SARS-CoV, MERS-CoV, RSV, and influenza virus using mice and non-human primates as model organisms.

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