New atomic-level insight of SARS-CoV-2 within a respiratory aerosol

new atomic level insight of sars cov 2 within a respiratory aerosol

Sumary of New atomic-level insight of SARS-CoV-2 within a respiratory aerosol:

  • In a paradigm-shifting paper currently available on the bioRxiv* preprint server, the researchers have dramatically extended the possibilities of computational microscopy in order to better understand both structure and dynamics of respiratory aerosols laden with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • Even though droplets have been seen as the main transmission route for SARS-CoV-2 – a causative agent of the ongoing coronavirus disease (COVID-19) pandemic – it quickly became apparent that airborne transmission also plays a pivotal role in disease spread.
  • However, the main challenge for understanding airborne transmission has been the inability to reliably examine the structure and dynamics of viruses once they become a part of respiratory aerosol particles.
  • This is why a recent paper from the Amaro group at the University of California San Diego completely revised contemporary models of viral airborne transmission by providing an unparalleled atomic-level understanding of SARS-CoV-2 within a respiratory aerosol.
  • Overall schematic depicting the construction and multiscale simulations of Delta SARS-CoV-2 in a respiratory aerosol.
  • ’ These types of simulations can give rise to multiple types of biological data (such as multiresolution structural datasets) into cohesive and biologically precise structural models.
  • Furthermore, such simulations can also yield specific parameters that can be incorporated into physical models of aerosols.
  • In addition, the researchers have also developed all-atom simulations of respiratory mucins to comprehend the structural foundation of interaction with the SARS-CoV-2 spike glycoprotein.

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