New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses

new vaccinia based covid 19 vaccine candidate induces robust durable immune responses

Sumary of New vaccinia-based COVID-19 vaccine candidate induces robust, durable immune responses:

  • Researchers in Australia have developed a coronavirus disease 2019 (COVID-9) vaccine that induced robust and long-lived humoral and cellular immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in both young and aging mice.
  • The team used the vaccinia virus-based Sementis Copenhagen Vector (SCV) to develop a vaccine encoding the SARS-CoV-2 spike glycoprotein that mediates viral attachment and entry into host cells.
  • This spike protein is a primary target of host immune responses following natural SARS-CoV-2 infection or vaccination.
  • Vaccinated mice rapidly developed robust spike-specific CD8 T cells and neutralizing antibody responses that significantly increased following a second dose.
  • Neutralizing antibody activity was maintained for up to nine months post-vaccination, and durable immune memory was evident.
  • The team – from the University of South Australia in Adelaide and Sementis Limited in Hackney – says the study data support the progression of SCV-based COVID-19 vaccine candidates towards efficacy testing in preclinical SARS-CoV-2 infectious disease challenge trials.
  • The challenges faced in COVID-19 vaccine design Since the COVID-19 outbreak first began in Wuhan, China, in late December 2019, the causative agent – SARS-CoV-2 – has infected more than 222 million people and claimed the lives of more than 4.59 million.
  • Fatality rates are disproportionately high in older individuals and those with co-morbidities such as diabetes, cardiovascular disease and immunosuppression.

Want to know more click here go to source.

From -

Close

Site Language


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close