Prefusion SARS-CoV-2 spike-based vaccine candidate shows high safety and efficacy in phase I trial

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Sumary of Prefusion SARS-CoV-2 spike-based vaccine candidate shows high safety and efficacy in phase I trial:

  • Many vaccines are being trialed against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the enveloped virus causing the current coronavirus disease 2019 (COVID-19) pandemic..
  • Newer and more effective vaccines are urgently required due to the rapid emergence of highly transmissible and perhaps more virulent virus lineages that often confer immune escape..
  • During this time, hundreds of thousands of severe COVID-19 cases will need to be treated, making new vaccines a priority to prevent the overwhelming of health services..
  • A new preprint research paper posted to the medRxiv* server reports the results of the first human trial of the prefusion stabilized SARS-CoV-2 spike vaccine MVC-COV1901 in Taiwan..
  • Stabilized vaccine design A vaccine must use an immunogenic antigen in the right conformation to elicit a protective neutralizing response..
  • In the current case, SARS-CoV-2 mediates attachment to the host cell via a receptor called the angiotensin-converting enzyme 2 (ACE2) by its spike protein..
  • To stabilize it in the prefusion state, a pair of proline residues is added to obtain S-2P – the stabilized prefusion S ectodomain of the spike protein..
  • Study details Related Stories The phase I study of MVC-COV1901 included 45 healthy adults between 20 and 49 years, who received two doses each, but in high, medium, and low dosages..
  • The spike-specific immunoglobulin G (IgG) antibody titer was markedly increased after the boost dose, with peak geometric mean titers (GMT) at 7,000 for the low-dosage group, 7,7000 for the medium dosage, and 11,000 for the high-dose groups, respectively..
  • The study thus shows that the MVC-COV1901 vaccine, a stabilized prefusion spike-based adjuvanted vaccine, is safe, well-tolerated, and immunogenic in healthy adults up to 49 years…

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