Prior symptomatic COVID-19 enhances mRNA vaccine response

prior symptomatic covid 19 enhances mrna vaccine response

Sumary of Prior symptomatic COVID-19 enhances mRNA vaccine response:

  • The coronavirus disease 2019 (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), originally emerged in Wuhan, China in December 2019. Since then, SARS-CoV-2 has infected over 226 million and caused the deaths of over 4.6 million worldwide.
  • The study findings suggest that one dose of a vaccine with high efficacy may be sufficient to protect the previously infected;
  • Study: Determinants of Early Antibody Responses to COVID-19 mRNA Vaccines In Exposed and Naive Healthcare Workers.
  • com Background The widespread rollout of COVID-19 vaccines significantly reduced hospitalizations and mortality in several developed countries.
  • The first vaccines to receive emergency approval were the Pfizer/BioNTech (BNT162b2) and Moderna (mRNA-95 1273) vaccines, both of which are based on messenger ribonucleic acid (mRNA) technology that encodes for the viral spike glycoprotein.
  • Both mRNA vaccines have demonstrated vaccine efficacies of 94% or above after a two-dose regimen in Phase III clinical trials.
  • Real-world effectiveness has also been shown to be high, though the efficacy has decreased against the currently dominant SARS-CoV-2 Delta variant of concern (VOC).
  • Limited supplies of vaccines in many countries have led to a re-examination of immunization policies in terms of a delayed second dose or putting naïve individuals at a higher priority for vaccination as compared to those with a previous history of natural infection.

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