Real-world proof Pfizer and Moderna mRNA vaccines prevent SARS-CoV-2 infection


Sumary of Real-world proof Pfizer and Moderna mRNA vaccines prevent SARS-CoV-2 infection:

  • Several randomized placebo-controlled Phase III trials have shown that messenger RNA (mRNA) vaccines for COVID-19 effectively prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection..
  • However, the effectiveness of these vaccines in preventing asymptomatic and symptomatic COVID-19 infections is not well understood..
  • Centers for Disease Control and Prevention (CDC) states that mRNA COVID-19 vaccines are highly effective in preventing SARS-CoV-2 infection in the real world..
  • The report is based on a CDC study where it routinely tested prospective cohorts of health care professionals, first responders, and essential and frontline workers for SARS-CoV-2 infections..
  • A total of 3,950 individuals were tested for 13 consecutive weeks regardless of symptom status and at the onset of symptoms associated with COVID-19–like illness..
  • In unvaccinated participants, 1.38 SARS-CoV-2 infections per 1,000 person-days were confirmed by reverse transcription-polymerase chain reaction (RT-PCR)..
  • In contrast, among the fully immunized individuals tested 14 days after the second dose of the vaccine, 0.04 infections were reported per 1,000 person-days..
  • In the partially immunized individuals tested 14 days after the first dose and before the second dose of the vaccine, 0.19 infections were detected per 1,000 person-days..
  • Related Stories Results show 90% and 80% effectiveness of mRNA vaccines in preventing SARS-CoV-2 infections in fully and partially immunized individuals, respectively The study results showed that the mRNA vaccine’s effectiveness for the prevention of SARS-CoV-2 infection was 90% under real-world conditions regardless of the status of symptoms and that for partially immunized individuals was 80%..
  • These findings have significant implications in public health as they show that authorized mRNA vaccines for COVID-19 are highly effective in preventing infections by SARS-CoV-2 in real-world conditions..
  • The findings of the CDC study complement and build upon preceding reports from studies by demonstrating that the mRNA vaccines are also effective in reducing the infection risk regardless of COVID-19–associated symptom status….

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