SARS-CoV-2 proteins manipulate autophagy

sars cov 2 proteins manipulate autophagy

Sumary of SARS-CoV-2 proteins manipulate autophagy:

  • The ongoing coronavirus pandemic (COVID-19) has claimed more than 4.1 million lives worldwide.
  • This pandemic is caused by a novel single-stranded RNA virus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was first reported in 2019 in Wuhan, China.
  • Autophagy is an evolutionarily ancient auto-digestive system that plays a vital role in the antiviral defenses of the host.
  • These viruses sometimes evolve to manipulate the autophagic machinery such that no inhibition is encountered during viral replication, membrane trafficking, and fusion processes.
  • SARS-CoV-2 reduces autophagic flux in humans Previous research has revealed that infection of human cells with SARS-CoV-2 decreases autophagic flux.
  • This experiment showed that SARS-CoV-2 could efficiently evade the antiviral functions of autophagy.
  • The molecular mechanism behind the evasion of antiviral functions of autophagy by SARS-CoV-2 A new study published in the journal Autophagy details a systematic analysis of the impacts of SARS-CoV-2 proteins on autophagy.
  • In this study, researchers analyzed the impact of 29 out of the 30 known SARS-CoV-2 proteins on autophagy.

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