Sumary of SARS-CoV-2 proteins manipulate autophagy:
- The ongoing coronavirus pandemic (COVID-19) has claimed more than 4.1 million lives worldwide.
- This pandemic is caused by a novel single-stranded RNA virus, namely, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was first reported in 2019 in Wuhan, China.
- Autophagy is an evolutionarily ancient auto-digestive system that plays a vital role in the antiviral defenses of the host.
- These viruses sometimes evolve to manipulate the autophagic machinery such that no inhibition is encountered during viral replication, membrane trafficking, and fusion processes.
- SARS-CoV-2 reduces autophagic flux in humans Previous research has revealed that infection of human cells with SARS-CoV-2 decreases autophagic flux.
- This experiment showed that SARS-CoV-2 could efficiently evade the antiviral functions of autophagy.
- The molecular mechanism behind the evasion of antiviral functions of autophagy by SARS-CoV-2 A new study published in the journal Autophagy details a systematic analysis of the impacts of SARS-CoV-2 proteins on autophagy.
- In this study, researchers analyzed the impact of 29 out of the 30 known SARS-CoV-2 proteins on autophagy.