SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction

sars cov 2 reprograms host chromatic network to induce immune dysfunction

Sumary of SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction:

  • A recent study conducted at the University of Texas Science Center, Houston, in the USA, has revealed that upon infection, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alters the host chromatin architecture to suppress antiviral interferon-responsive genes and augment inflammatory genes.
  • Background SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped, positive-sense, single-stranded RNA virus that primarily attacks epithelial cells in the human respiratory tract.
  • The entire mammalian chromatin network contains several layers of architectures, including A/B compartments, Topological Associating Domains (TADs), and chromatin loops, which collectively regulate vital nuclear functions, including gene transcription, replication, recombination, and DNA damage repair.
  • With further analysis, the scientists observed that chromatin domains are frequently weakened, and chromatin loops are frequently deregulated.

Want to know more click here go to source.

From -

Close
Generic selectors
Exact matches only
Search in title
Search in content

Site Language


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close