Sumary of SARS-CoV-2 reprograms host chromatic network to induce immune dysfunction:
- A recent study conducted at the University of Texas Science Center, Houston, in the USA, has revealed that upon infection, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) alters the host chromatin architecture to suppress antiviral interferon-responsive genes and augment inflammatory genes.
- Background SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped, positive-sense, single-stranded RNA virus that primarily attacks epithelial cells in the human respiratory tract.
- The entire mammalian chromatin network contains several layers of architectures, including A/B compartments, Topological Associating Domains (TADs), and chromatin loops, which collectively regulate vital nuclear functions, including gene transcription, replication, recombination, and DNA damage repair.
- With further analysis, the scientists observed that chromatin domains are frequently weakened, and chromatin loops are frequently deregulated.