Statins associated with reduced COVID-19 mortality and decreased need for ventilator support


Sumary of Statins associated with reduced COVID-19 mortality and decreased need for ventilator support:

  • Statins help lower serum lipids by blocking HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase), the rate-limiting enzyme of cholesterol biosynthesis..
  • Theoretically, since ACE2 is the entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), chronic use of statins could increase susceptibility to COVID-19..
  • Investigating the effect of statin use on COVID-19 outcomes Researchers from the Republic of China recently conducted a study to investigate the association between statin use and COVID-19 outcomes and identify the population subgroup that can benefit from the use of statins..
  • They performed a systematic review and meta-analysis of previously published studies on statin users and COVID-19 outcomes..
  • The results showed that statin use was significantly associated with reduced all-cause mortality and the need for IMV in COVID-19 patients..
  • Subgroup analysis identified five types of studies in which patients taking statins had lower chances of death..
  • Related Stories Subgroup analysis showed that the use of statins prevented more deaths in studies that had a case fatality rate (CFR) under 20% compared to studies with a CFR of over 20%..
  • The findings of this analysis showed that participants with COVID-19 in 5 types of studies had lower odds of death while on statins….

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