Study examines the effects of COVID-19 on human kidney cells

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Sumary of Study examines the effects of COVID-19 on human kidney cells:

  • Many individuals who develop COVID-19 also experience kidney damage, but it’s unclear if this is a direct result of viral infection or a consequence of another condition or the body’s response to the infection..
  • To investigate, a team led by Benjamin Dekel, MD, PhD (Sheba Medical Center, in Israel) cultivated human kidney cells in lab dishes and infected them with the virus that causes COVID-19..
  • The researchers found that although the virus that causes COVID-19 could enter, infect, and replicate in human adult kidney cells, this did not typically lead to cell death..
  • Prior to infection, the cells contained high levels of interferon signaling molecules, and the infection stimulated an inflammatory response that increased these molecules..
  • In contrast, infection of kidney cells deficient in such molecules resulted in cell death, suggesting a protective effect..
  • The cells in these experiments were grown as a three-dimensional spheroid that imitates the healthy kidney or as a two-dimensional layer that mimics the cells of an acutely injured kidney..
  • Cells that mimicked an acutely injured kidney were more prone to infection and additional injury but not cell death..
  • Therefore, if we’re able to limit the common scenario of acute kidney injury in the first place, then there might be the possibility to minimize potential damage caused by the virus,”…

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