Study identifies how COVID-19 linked to Alzheimer’s disease-like cognitive impairment

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Sumary of Study identifies how COVID-19 linked to Alzheimer’s disease-like cognitive impairment:

  • A new Cleveland clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer disease-like dementia..
  • The findings, published in Alzheimer Research and Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment..
  • Reports of neurological complications in COVID-19 patients and ‘long haulier’ patients whose symptoms persist after the infection clears are becoming more common, suggesting that SARS-CoV-2 (the virus that causes COVID-19) may have lasting effects on brain function..
  • “While some studies suggest that SARS-CoV-2 infects brain cells directly, others found no evidence of the virus in the brain,”.
  • says Feixiong Cheng, PhD, assistant staff in Cleveland Clinic Genomic Medicine Institute and lead author on the study..
  • In the study, the researchers harnessed artificial intelligence using existing datasets of patients with Alzheimer and COVID-19..
  • They measured the proximity between SARS-CoV-2 host genes/proteins and those associated with several neurological diseases where closer proximity suggests related or shared disease pathways..
  • To explore this further, they investigated potential associations between COVID-19 and neuroinflammation and brain microvascular injury, which are both hallmarks of Alzheimer ….

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