Study identifies mechanisms by which COVID-19 can lead to Alzheimer’s disease-like dementia

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Sumary of Study identifies mechanisms by which COVID-19 can lead to Alzheimer’s disease-like dementia:

  • A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer’s disease-like dementia..
  • Therapy, indicate an overlap between COVID-19 and brain changes common in Alzheimer’s, and may help inform risk management and therapeutic strategies for COVID-19-associated cognitive impairment..
  • patients whose symptoms persist after the infection clears are becoming more common, suggesting that SARS-CoV-2 (the virus that causes COVID-19) may have lasting effects on brain function..
  • While some studies suggest that SARS-CoV-2 infects brain cells directly, others found no evidence of the virus in the brain..
  • Feixiong Cheng, PhD, Study Lead Author and Assistant Staff, Cleveland Clinic, Genomic Medicine Institute In the study, the researchers harnessed artificial intelligence using existing datasets of patients with Alzheimer’s and COVID-19..
  • They measured the proximity between SARS-CoV-2 host genes/proteins and those associated with several neurological diseases where closer proximity suggests related or shared disease pathways..
  • To explore this further, they investigated potential associations between COVID-19 and neuroinflammation and brain microvascular injury, which are both hallmarks of Alzheimer’s..
  • “We discovered that SARS-CoV-2 infection significantly altered Alzheimer’s markers implicated in brain inflammation and that certain viral entry factors are highly expressed in cells in the blood-brain barrier,”…

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