Updated mapping of the human genetic architecture of COVID-19

updated mapping of the human genetic architecture of covid 19

Sumary of Updated mapping of the human genetic architecture of COVID-19:

  • The coronavirus disease 2019 (COVID-19) pandemic has been caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and continues to pose a major public health threat, especially in countries with low vaccination rates.
  • It is important to understand better the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, to inform public health measures.
  • Study: Mapping the human genetic architecture of COVID-19: an update.
  • c/ Shutterstock A new study In the present study, researchers presented extensive meta-analysis and added ten new genome-wide significant loci.
  • Genes in the novel loci included SFTPD, MUC5B, and ACE2 and revealed significant insights regarding disease susceptibility and severity.
  • Scientists presented meta-analyses for three COVID-19 related phenotypes.
  • The second considered cases with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases and 2,836,272 33 controls).
  • Researchers found 23 genome-wide significant loci, of which 20 remained significant after multiple testing corrections to consider the number of phenotypes examined.

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