Dynamic heart model mimics hemodynamic loads, advances engineered heart tissue technology

dynamic heart model mimics hemodynamic loads advances engineered heart tissue technology

Sumary of Dynamic heart model mimics hemodynamic loads, advances engineered heart tissue technology:

  • However, using cells from patients with certain types of heart disease, these same exercise-like loads can result in heart muscle dysfunction.
  • “One of the really important things about this work is that it’s a collaborative effort between our lab and collaborators in the Netherlands, including Cardiologist Peter van der Meer,” says Feinberg.
  • “Peter treats patients that have genetically-linked cardiovascular disease, including a type called arrhythmogenic cardiomyopathy (ACM) that often becomes worse with exercise.
  • We have been able to get patient-specific induced pluripotent stem cells, differentiate these into heart muscle cells, and then use these in our new EHT model to recreate ACM in a petri dish, so we can better understand it.

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