Sumary of Dynamic heart model mimics hemodynamic loads, advances engineered heart tissue technology:
- However, using cells from patients with certain types of heart disease, these same exercise-like loads can result in heart muscle dysfunction.
- “One of the really important things about this work is that it’s a collaborative effort between our lab and collaborators in the Netherlands, including Cardiologist Peter van der Meer,” says Feinberg.
- “Peter treats patients that have genetically-linked cardiovascular disease, including a type called arrhythmogenic cardiomyopathy (ACM) that often becomes worse with exercise.
- We have been able to get patient-specific induced pluripotent stem cells, differentiate these into heart muscle cells, and then use these in our new EHT model to recreate ACM in a petri dish, so we can better understand it.