Research in mice shows how diet alters immune system function through a gut microbe

research in mice shows how diet alters immune system function through a gut microbe

Sumary of Research in mice shows how diet alters immune system function through a gut microbe:

  • Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.
  • While scientists have surmised for a long time that diet plays a role in immune health, the new study elucidates the precise molecular cascade behind this interplay, said study senior author Dennis Kasper, professor of immunology in the Blavatnik Institute at Harvard Medical School.
  • ” If confirmed in larger animals and eventually in humans, the findings can help inform the design of small-molecule treatments that enhance both intestinal and overall immunity, the researchers said.
  • “Gut-resident microbes produce molecules with enormous structural diversity.
  • “Our findings yield fascinating insights about the microbiome, diet, and immune function and provide interesting clues about how molecules made by our inner neighbors can be used to design therapies.
  • fragilis, a gut-resident microbe, and converted by a specific enzyme into sugar-lipid molecules that also have branched chains.
  • fragilis then releases branched-chain molecules that are spotted and picked up by a class of immune-signaling cells known as antigen-presenting cells, which in turn induce NK T cells to exercise their immunoregulatory response through upregulating inflammation-controlling genes and immune-regulatory chemicals.
  • Straight-chain versions of the molecule did not yield the same effect.

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