Sumary of Revealing the secrets of cell competition:
- However, the features that distinguish “winner” from “loser” cells and whether there are key determinants for cell competition in various biological contexts remain elusive.
- Using single-cell RNAseq (a specific sequencing technique), the researchers compared cells in embryos treated with a cell death inhibitor versus those in untreated mouse embryos.
- By applying machine learning algorithms, they could identify the gene expression signature of “loser” cells and discovered that these cells have defective mitochondria and are marked by sequence changes in their mitochondrial genome.
- Future work This study suggests that mitochondrial activity may be a key determinant of cellular fitness in a variety of contexts where competition between cells occurs.