Sumary of Structural changes in receptor-binding interface may induce immune fitness of SARS-CoV-2 delta variant:
- Florida International University researchers have investigated the mutation-induced structural changes in the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could contribute to its immune evasion abilities.
- The scientists have identified that certain alterations in the receptor-binding interface facilitate the delta variant escaping antibody-mediated neutralization.
- Background Among various genetic variants of SARS-CoV-2 identified so far, the B.
- 1.617.2 variant, also called the delta variant, is considered to have the highest infectivity.
- Soon after its first identification in India, the delta variant sparked a second wave of devastating complications which has sapped the country’s economy and healthcare system.
- Given its rapid and exponential spread within and outside India, the delta variant has been designated as the Variant of Concern (VOC) by the World Health Organization.
- Although currently available vaccines have shown neutralizing efficacy against the delta variant, evidence suggests that neutralizing antibodies induced by natural SARS-CoV-2 infection or vaccination are relatively less effective against the variant.
- In the current study, the scientists have investigated how mutation-induced structural changes in the receptor-binding interface of the delta variant affect its binding to angiotensin-converting enzyme 2 (ACE2) and neutralizing antibodies.