A genetic link to molecular events that precede symptoms in Alzheimer’s disease

a genetic link to molecular events that precede symptoms in alzheimers disease

Sumary of A genetic link to molecular events that precede symptoms in Alzheimer’s disease:

  • Of enzymes traveling up and down neuronal axons, leading to the accumulation of amyloid beta — a key feature and cause of Alzheimer’s disease..
  • The enzyme, BACE1, gets backed up, causing the axons to clog and swell because of the increased production of the toxic amyloid protein..
  • “In individuals with Alzheimer’s disease, the onset of symptoms happens about 20 years after the first changes start to develop in the brain, making therapeutic intervention extremely difficult,”.
  • Tufts researchers previously identified a gene, Gga3, which helps regulate the traffic of BACE1, or beta-site APP-cleaving enzyme 1, along the axon..
  • Although the sample size was small, the researchers believe this finding may provide a case for identifying early stage interventions and treatments for this group of patients…

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