Sumary of Cholesterol drives Alzheimer’s plaque formation:
- Cholesterol manufactured in the brain appears to play a key role in the development of Alzheimer’s disease, new research indicates.
- Scientists from the University of Virginia School of Medicine and their collaborators found that cholesterol produced by cells called astrocytes is required for controlling the production of amyloid beta, a sticky protein that builds up in the brains of patients with Alzheimer’s.
- The new findings offer important insights into how and why the plaques form and may explain why genes associated with cholesterol have been linked to increased risk for Alzheimer’s.
- The results also provide scientists with important direction as they seek to prevent Alzheimer’s.
- “This study helps us to understand why genes linked to cholesterol are so important to the development of Alzheimer’s disease,” said researcher Heather A.
- “Our data point to the importance of focusing on the production of cholesterol in astrocytes and the transport to neurons as a way to reduce amyloid beta and prevent plaques from ever being formed.
- ” Alzheimer’s Plaques and Cholesterol While cholesterol is often associated with clogged arteries and heart disease, it plays important roles in the healthy body.
- The body makes cholesterol naturally so it can produce hormones and carry out other important functions.