Gamma-secretase ‘buckles up’ to reach its destination

gamma secretase buckles up to reach its destination

Sumary of Gamma-secretase ‘buckles up’ to reach its destination:

  • A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer’s disease.
  • In a first step, two dimeric subcomplexes are formed, which independently exit the ER and only afterwards assemble into a four-subunit complex.
  • This ‘buckle up’ mechanism is thought to prevent premature assembly and activity.
  • An enzyme complex involved in plaque production Gamma-secretase is best known as the enzyme that cleaves the amyloid precursor protein, generating a small peptide called amyloid beta, the main constituent of the plaques found in the brains of people affected by Alzheimer’s disease.
  • Ever since the discovery of its implication in disease, gamma-secretase has been studied and tested as a potential therapeutic target, but its role in the body is much broader than producing amyloid.
  • We now know that gamma-secretase is a complex made up of four components, two of which have multiple homologues, resulting in variety of complexes with distinct subcellular distributions, providing a basis for substrate selectivity.
  • But how these four subunits get assembled in such stable enzyme complexes remained unknown until now.
  • Dissecting the assembly line The Annaert lab at the VIB-KU Leuven Center for Brain &

Want to know more click here go to source.

From -

Close
Generic selectors
Exact matches only
Search in title
Search in content

Site Language


By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close