Major depressive episodes after COVID-19 illness differ from typical presentation


Sumary of Major depressive episodes after COVID-19 illness differ from typical presentation:

  • Apparent major depressive episodes after COVID-19 illness appeared distinct from those usually observed among adults, according to results of a survey study in a research letter published in JAMA Network Open..
  • “A key question is whether such symptoms represent a general consequence of stress associated with acute illness or whether they reflect more specific sequelae associated with COVID-19 pathophysiology itself..
  • To examine this possibility, in this survey study, we compared features of major depression in individuals with or without prior COVID-19 illness.”.
  • The researchers used a multipanel commercial vendor to conduct 12 waves of an internet nonprobability Qualtrics survey approximately every month between May 2020 and February 2021 among people aged 18 years or older..
  • Participants reported if and when they had COVID-19 illness according to clinician diagnosis or if they had a positive SARS-CoV-2 test results..
  • They completed the Patient Health Questionnaire-9 (PHQ-9) to measure depressive symptoms, with having at least moderate symptoms defined as a score of 10 or higher..
  • Logistic regression with moderate or greater depressive symptoms served as the dependent variable and sociodemographic features as independent variables..
  • Further, 6.5% reported prior COVID-19 clinician diagnosis or test result and 31.2% reported moderate or greater depressive symptoms….

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