Parkinson’s disease: How lysosomes become a hub for the propagation of the pathology

parkinsons disease how lysosomes become a hub for the propagation of the pathology

Sumary of Parkinson’s disease: How lysosomes become a hub for the propagation of the pathology:

  • α-syn fibrils spreads through TNTs inside lysosomes In 2016, a team of researchers from the Institut Pasteur (Paris) and the French National Centre for Scientific Research (in French: CNRS, Centre national de la recherche scientifique) demonstrated that α- syn fibrils spread from donor to acceptor cells through tunneling nanotubes (TNTs).
  • “TNTs are actin-based membrane channels allowing the transfer of several cellular components including organelles between distant cells.
  • Lysosomes are organelles normally deputed to the degradation and recycling of toxic/damaged cell material” describes Chiara Zurzolo, head of the Membrane Traffic and Pathogenesis Unit at the Institut Pasteur.

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