Polygenic scores may identify long-term risk for depression, resilience

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Sumary of Polygenic scores may identify long-term risk for depression, resilience:

  • Multivariate polygenic score profiles may help identify long-term risk for depression and resilience, according to results of a longitudinal cohort study published in JAMA Psychiatry..
  • To address this research gap, Schultebraucks and colleagues aimed to evaluate the discriminatory accuracy of a deep neural net that combined joint information from 21 polygenic scores related to psychiatry and health for distinguishing resilience from other longitudinal symptom trajectories by using longitudinal, genetically informed data of adults with major life stressor exposure..
  • They analyzed data of 2,017 participants of the longitudinal panel cohort study the Health and Retirement Study who were aged older than 50 years, of European ancestry and had data available on depressive symptom trajectory information after having experienced an index depressogenic major life stressor..
  • Major life stressors included bereavement, divorce and job loss or major health events, such as myocardial infarction and cancer….

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