Sumary of Signs of dementia are written in the blood, reveals new study:
- The study revealed that the levels of 33 metabolites differed in patients with dementia, compared to elderly people with no existing health conditions.
- “Metabolites are chemical substances produced by vital chemical reactions that occur within cells and tissues,” said first author Dr. Takayuki Teruya, who works in the G0 Cell Unit at the Okinawa Institute of Science and Technology Graduate University (OIST).
- Of all aging-associated diseases, dementia is one of the most serious, not only for the patients and their family but for society as a whole, with an estimated 55 million people living with the disease worldwide.
- In the study, the research team analyzed samples of blood collected from eight patients with dementia, as well as eight healthy elderly people.
- They also collected samples from eight healthy young people to use as a reference.
- Unlike most studies analyzing blood metabolites, this research included compounds found within red blood cells.
- However, the research team recently developed a way to stabilize metabolites in red blood cells, allowing them to examine for the first time the relationship between red blood cell activity and dementia.
- The research team plans to test this idea in the next steps of their research, by seeing if increases in these metabolites can induce dementia in animal models, like mice.