Study sheds light on treatment options for devastating childhood brain cancer

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Sumary of Study sheds light on treatment options for devastating childhood brain cancer:

  • However, the radiation used to treat such tumors takes a toll on the brain, damaging cognitive function, especially in younger patients whose brains are just beginning to develop..
  • But the researchers also found that the dose of the preventive radiation treatments given to the whole brain and spine over the six-week regimen cannot be reduced without reducing survival..
  • Further, the researchers showed that patients’ cancers responded differently to therapy depending on the biology of the tumors, setting the stage for future clinical trials of more targeted treatments..
  • Children with average risk medulloblastoma typically undergo surgery to remove as much of the tumor as possible..
  • They also receive chemotherapy and radiation therapy to prevent the spread of the tumor to other parts of the brain and spine through the cerebrospinal fluid..
  • “We wanted to investigate whether we could safely reduce the amount of radiation these patients receive — sparing normal parts of the brain and lessening the side effects for children with this type of brain cancer — while also maintaining effective treatment,”.
  • “We found that reducing the dose of radiation received over the six-week course of treatment had a negative impact on survival..
  • But we also found that we could safely reduce the size of the volume of the brain that receives a radiation boost at the end of the treatment regimen….

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