Why drug used to treat critically ill COVID-19 patients may only benefit males

why drug used to treat critically ill covid 19 patients may only benefit males

Sumary of Why drug used to treat critically ill COVID-19 patients may only benefit males:

  • A new study from the University of Calgary shows how dexamethasone, the main treatment for severe COVID-19 lung infections, alters how immune cells work, which may help male patients, but has little to no benefit for females.
  • “We found that the males derived benefit from the steroids, and the females, at both the cellular level and at the population level, received limited benefit,” says Yipp, Tier II Canada Research Chair in Pulmonary Immunology, Inflammation and Host Defense.
  • At the onset of the pandemic, hospitals’ treatments of the severely ill were not yet informed by research into how effective the drugs were under COVID-19 conditions.
  • “To be able to develop new treatments, we wanted to study how different people respond to SARS-CoV2 infection and how different immune responses dictate the severity of their disease,” says Biernaskie, the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing.
  • ” Analyzing thousands of immune cells from ICU patients Blood was collected from both COVID-19 and non-COVID-19 patients who were admitted to Calgary ICUs in severe respiratory distress.
  • Researchers in the Biernaskie lab used cutting-edge single cell RNA sequencing and bioinformatics techniques to simultaneously analyze the functional states of thousands of immune cells from each patient.
  • This allowed them to document cellular behaviours at different stages of the disease (COVID-19 or non-COVID infections) and to measure treatment effects.

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