Drug Used to Prevent Miscarriage May Raise Lifetime Cancer Risk in Offspring

drug used to prevent miscarriage may raise lifetime cancer risk in offspring

Sumary of Drug Used to Prevent Miscarriage May Raise Lifetime Cancer Risk in Offspring:

  • Researchers found the increased cancer risk among adults whose mothers had been given injections of a synthetic progesterone known as 17-OHPC, or 17P, during pregnancy.
  • However, the effectiveness of 17P against preterm birth has been called into question by recent research.
  • “It’s important to think about the potential long-term effects of what we give during pregnancy on the health of offspring,” said Murphy, an associate professor at UTHealth School of Public Health in Houston.
  • The findings, recently published in the American Journal of Obstetrics and Gynecology, are based on more than 18,000 mother-child pairs who were followed from the time of the mothers’ pregnancy, between 1959 and 1966. As of 2019, 1,008 of those offspring had been diagnosed with cancer.
  • That risk, Murphy’s team found, was 2.6 times higher among people whose mothers had been given 17P during pregnancy.
  • ” She noted that there is a precedent: Prior to 1971, a synthetic form of estrogen called DES was prescribed to help prevent miscarriages and preterm births.
  • But in 2003, a U.S. government-funded trial found that 17P lowered the risk of preterm birth in women with a history of it.

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