Sumary of Largest genetic study identifies new drug targets to treat type 1 diabetes:
- Scientists have completed the largest and most diverse genetic study of type 1 diabetes ever undertaken, identifying new drug targets to treat a condition that affects 1.3 million American adults.
- Drugs targeting 12 genes identified in the diabetes study have been tested or are being tested in clinical trials for autoimmune diseases.
- That could accelerate the drugs’ repurposing for treating or preventing type 1 diabetes, the researchers say.
- “Using these results, we hope that the number of plausible genetic variants will be reduced, their function and gene targets clarified, and existing drugs used in other diseases can be tested for their impact on delaying onset of type 1 diabetes, or improved treatment outcomes.
- ” About type 1 diabetes Formerly known as juvenile diabetes, type 1 diabetes can affect both children and adults.
- In type 1 diabetes, the body’s own immune system attacks the insulin-producing beta-cells in the pancreas, such that the body doesn’t make enough insulin, a hormone that helps the body burn sugar as fuel.
- Type 1 diabetes increases the risk for heart problems, stroke, nerve damage and vision loss, and can even cause pregnancy complications and miscarriages.
- The new type 1 diabetes study examined 61,427 participants, which is twice the size of the previous largest study.